Abstract We investigated the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with post-stroke dysphagia (PSD). Functional near infrared spectroscopy (fNIRS) was used to investigate its possible mechanism.Patients with PSD were randomised into the intervention (rTMS) or control (shame rTMS) group.Along with conventional swallowing therapy,the rTMS group received high-frequency rTMS of the mandibular hyoid cortical region at 5 hz, and the sham rTMS group received sham stimulation. Both groups received a course of six weekly sessions for 2 weeks.At baseline and two weeks later, standardized swallowing Assessment , Penetration-Inhalation Scale and other scales were used to assess swallowing function.At the same time, we used fNIRS to detect cerebral hemodynamic changes in both groups.Two weeks after baseline, clinical assessment of swallowing function improved in both groups compared to the previous results. The results of our fNIRS subgroup analyses showed that enhanced activation mainly in dorsolateral prefrontal cortex,primary somatosensory cortex and primary motor cortex in the left group. In the right group, activation of the primary somatosensory cortex was enhanced.Our findings demonstrate that high-frequency rTMS on the healthy side improves activation of swallowing-related brain regions in PSD patients, which may help to further explore the mechanisms of recovery in PSD.
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Liu et al. (2024) studied this question.
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