Determination of Left Main Coronary Artery Luminal Area Using CT Angiography in Individuals with Un-Obstructive Coronary Arteries

Objective: To assess the Minimal Luminal Area of the left main coronary artery in cardiac patients having un-obstructed coronary arteries. Study Design: Analytical, Cross-sectional study. Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan, from April-Sep 2023. Methodology: Total eighty six individuals with low risk pre-test probability for Coronary artery disease (via CAD consortium calculator) underwent a CT angiogram and their Left Main Coronary Artery Minimal Luminal Area was calculated using dedicated software over a 2-month period. Approval from the Ethical Review Board was sought. Sampling was done by using non-probability consecutive sampling. Student t-test was applied to find the mean difference of LM-MLA between factors such as diabetes mellitus, hypertension, gender, and smoking status with Minimal Luminal Area. Pearson correlation was applied to find correlation between Left Main Coronary Artery Minimal Luminal with age, BMI, BSA, and LV-mass. p<0.05 was taken as statistically significant. Results: Out of total n=86 individuals, 67(77.9%) were males and 19(22.1%) were females with average age of 45.78±11.40 years. The mean Minimal Luminal Area of study sample was 12.07±4.17mm2 with males having a mean Minimal Luminal Area of 12.79±4.31mm2 and females having a mean MLA of 9.50±2.26mm2. It was noted that an increased LV mass leads to an increase in LM-MLA (r=0.579, p < 0.001). Conclusion: Variety of factors influence the Left Main Coronary Artery Minimal Luminal which means local guidelines would have to be set up to dictate treatment threshold in patients with ...