Fighting Biofilm Bearing Microbes, Global Challenges, Initiatives and Current Novel Therapeutics/Antibiofilm Strategies: A Narrative Scientific Record

Microbial survival against diverse anti-biocidal agents has advance beyond single organism interaction into intricate sessile cells consisting dynamic three-dimensional extracellular complex matrix of water channels. Such complex architecture is built with heterogeneous and variable components that encourage failure of antimicrobial-chemotherapeutic strides especially among biofilm bearing/expressing microbes (BBM). This is a noteworthy public health concern as such occurrence has welcomed global attention in recent times with focus on fighting BBM as well as exploration of novel therapeutic strategies. A narrative scientific description of biofilm as a community of microbes wrapped in extracellular polymeric substances (EPS) was reviewed. The challenges on disease/infection recalcitrance, risk to public health and the necessity to develop novel therapeutics for the management/control and suppression of biofilm linked infections were emphasized. It also summarized potential approaches including the use of antibiofilm/anti-adhesion agents, antimicrobial proteins (AMPs), aptamers, Nano-Particulates (NPs), quorum sensing inhibitors (QSIs), and peptide or protein-based nucleic acids (PNAs) while discussing the agents efficient potential ability. Such anti-biofilm agents/mechanisms and their target-specific-therapeutic relevance promises future for the management/control of biofilm associated microbial infections. Its application may also herald a generational effective combination therapy against illnesses/infections caused by BBM and served as a potential source for BBM global control.