Preclinical murine study demonstrates delayed fracture healing with dysregulated local immune response in progeria, highlighting a small animal model for impaired repair.
Bone fracture is one of the most globally prevalent injuries, with an estimated 189 million bone fractures occurring annually. Delayed union or nonunion occurs in up to 15% of fractures and involves the interruption or complete failure of bone continuity following fracture. Preclinical testing is essential to support the translation of novel strategies to promote improved fracture repair treatment, but there is a paucity of small animal models that recapitulate clinical attributes associated with delayed fracture healing. This study explores whether the
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Duke et al. (2024) studied this question.
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