A pilot study on the time-specific effects of light exposure from a light emitting diode (LED) on cardiovascular development in Danio rerio

Exposure to illumination from LED (light emitting diode) light may be an unsuspecting cause of human health problems, including cellular growth disruptions and cardiovascular issues. Vertebrate hearts comprise multiple chambers that create a rhythm resulting in continuous blood flow, which, if insufficient results in the heart retaining fluid. Here we report a preliminary study of the effect of exposing wild-type Danio rerio (zebrafish) embryos to 6500K, White, LED light on development of pericardial edema. Embryos were exposed to LED light from 12 hours post fertilization for 72 hours in one of the following conditions: (1) no exposure, (2) light/dark cycle of 12 hours/12 hours, and (3) 72 consecutive hours. Results indicated a significant relationship between exposure to LED lighting and pericardial edema; a significant relationship was seen between length of exposure and severity of pericardial edema. Pericardial edema became noticeable after 48 hours of light exposure. Further research should explore the effects of different wavelengths of LEDs on development of pericardial edema. Molecular studies might examine how LED exposure alters transcription factors involved in cardiac development.