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May 28, 2024CellsOpen Access

Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury

Bipul Ray Wiramon Rungratanawanich Karli R. LeFort Saravana Babu Chidambaram Byoung‐Joon Song

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Abstract

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) metabolizes acetaldehyde to acetate. People with ALDH2 deficiency and

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Cite This Study

Ray et al. (2024) studied this question.

synapsesocial.com/papers/68e680e5b6db643587609909 https://doi.org/10.3390/cells13110927

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The role of ALDH2 and its substrates in central nervous system disorders2024 · 1 citations
2Mitochondrial Aldehyde Dehydrogenase, A Potential Drug Target for Protection of Heart and Brain from Ischemia/Reperfusion Injuryreview · 2014 · 34 citations
3Targeting Aldehyde Dehydrogenase 2: New Therapeutic OpportunitiesReview · 2014 · 614 citations
4ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases2025 · 5 citations
5Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations2024 · 1 citations

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Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE2020
Aldehyde dehydrogenase-2 modulates acrolein toxicity to promote neural repair after spinal cord injury2026

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