Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity

firstₚage Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity † by Ekhlakh VegEkhlakh Veg SciProfiles Scilit Preprints. org Google Scholar 1, 2, *, Seema JoshiSeema Joshi SciProfiles Scilit Preprints. org Google Scholar 2 and Tahmeena KhanTahmeena Khan SciProfiles Scilit Preprints. org Google Scholar 1, * 1 Department of Chemistry, Integral University, Lucknow 226026, UP, India 2 Department of Chemistry, Isabella Thoburn College, Lucknow 226007, UP, India * Authors to whom correspondence should be addressed. † Presented at the 3rd International Electronic Conference on Processes—Green and Sustainable Process Engineering and Process Systems Engineering (ECP 2024), 29–31 May 2024; Available online: https: //sciforum. net/event/ECP2024. Proceedings 2024, 105 (1), 50; https: //doi. org/10. 3390/proceedings2024105050 Published: 28 May 2024 (This article belongs to the Proceedings of The 3rd International Electronic Conference on Processes—Green and Sustainable Process Engineering and Process Systems Engineering) Download keyboardₐrrowdown Download PDF Download PDF with Cover Download XML Download Epub Download Supplementary Material Versions Notes Keywords: fabrication; thiosemicarbazone; nanocomposite; therapeutic Introduction: Thiosemicarbazone (TSC) derivatives and their complexes have emerged as versatile medicinal agents. Now, the focus has shifted to targeted drug delivery, and here, the application of nanotechnology is being explored. Nanoparticle (NP) technologies are being explored, owing to their tremendous medicinal applications. They are also being explored to overcome the water insolubility of medicinal agents and for their ability to target specific targets. Methods: This article aims at exploring the fabrication strategies and applications of functionalized TSCs conjugated with NPs for improved therapeutic potential. Studies were taken from the recent literature, and are indexed in leading databases. Results: The literature survey reveals the fabrication of TSCs with chitosan-coated superparamagentic magnetite NPs, which showed significant anti-proliferative activity against a number of cell lines. Similarly, cobalt oxide nanoparticles conjugated with TSCs have been tested against hepatic cancer cell line HepG2. Other than for their anticancer activity, the functionalized nanoparticles have also been employed against drug-resistant pathogens. To improve oral bioavailability and pharmacological activity, nanoparticle-based block polymers have been proposed to encapsulate the TSCmoiety. The in vitro activity of the fabricated NPs was tested against Leishmania amazonensis. Against microphages, less cytotoxicity was observed. Conclusions: The article may shed light on the structure–bioactivity relationship of novel nanocomposites derived from TSCs and NPs and their specific mechanisms of action. Supplementary MaterialsThe following supporting information can be downloaded at: https: //www. mdpi. com/article/10. 3390/proceedings2024105050/s1, Conference poster. Author ContributionsInvestigation, formal analysis, writing—original draft, E. V. ; co-supervision, writing—review and editing, S. J. ; supervision, methodology, writing—proof reading, T. K. All authors have read and agreed to the published version of the manuscript. FundingThe research received no external funding. Institutional Review Board StatementNot applicable. Informed Consent StatementNot applicable. Data Availability StatementNo new data was generated during the study. AcknowledgmentsThe authors are thankful to the R Joshi, S. ; Khan, T. Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity. Proceedings 2024, 105, 50. https: //doi. org/10. 3390/proceedings2024105050 AMA Style Veg E, Joshi S, Khan T. Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity. Proceedings. 2024; 105 (1): 50. https: //doi. org/10. 3390/proceedings2024105050 Chicago/Turabian Style Veg, Ekhlakh, Seema Joshi, and Tahmeena Khan. 2024. "Design and Fabrication of Heterojunctions of Thiosemicarbazones and Metallic Nanoparticles in Search of Their Medicinal Activity" Proceedings 105, no. 1: 50. https: //doi. org/10. 3390/proceedings2024105050 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.