FIGURE 2 from Comparative Epigenetic Profiling Reveals Distinct Features of Mucosal Melanomas Associated with Immune Cell Infiltration and Their Clinical Implications

Association of epigenetic features with prognosis in patients with PMME. A, Comparison of methylation levels of selected DMRs (statistically significant in multivariate analysis) among PMME, NEMM, and normal controls. B, Kaplan–Meier curve of OS of patients with PMME stratified on the basis of the risk score derived from the 7-DMR panel–based COX model. C, ROC curve depicting the prediction performance of 7-DMR panel–based COX model for patients survival status at 12, 18, and 24 months, assessed using LOOCV. Kaplan–Meier curve of OS in the entire queue of patients with mucosal melanomas (D) and inTCGA-SKCM cohort stratified on the basis of the risk score derived from the 7-DMR panel–based COX model (E).