FIGURE 1 from Comparative Epigenetic Profiling Reveals Distinct Features of Mucosal Melanomas Associated with Immune Cell Infiltration and Their Clinical Implications

PMME had a distinct epigenetic profile when compared with NEMM and normal controls. A, Schematic representation of the study design and methodology. Methyl-seq, methylation sequencing; mIF, multiplex immunofluorescence; QC, quality control. B, The number of hypermethylated and hypomethylated DMRs between PMME, NEMM, and normal controls. C, The unsupervised clustering of DMRs in the promoter regions between PMME and normal controls. D, The unsupervised clustering of DMRs in the promoter regions between PMME and NEMM.