FIGURE 4 from Comparative Epigenetic Profiling Reveals Distinct Features of Mucosal Melanomas Associated with Immune Cell Infiltration and Their Clinical Implications

Role of TERT hypermethylation in PMME and its impact on immunologic signatures. A, Heat map depicting the association between hypermethylated genes and the immune cell infiltration in PMME. B, Linear regression analysis demonstrating the correlation between TERT methylation and immune infiltration in PMME. C, Comparison of TERT methylation levels among PMME, NEMM, and controls (*, P < 0.05; **, P < 0.01; ***, P < 0.001). D, Comparison of TERT expression levels among PMME tumors, NEMM, and controls.