FIGURE 6 from Comparative Epigenetic Profiling Reveals Distinct Features of Mucosal Melanomas Associated with Immune Cell Infiltration and Their Clinical Implications

Association between TERT hypermethylation and immunotherapy responses. A, Significant immune-related pathways that were derived from GSEA of TERT methylation-related genes when comparing PMME and NEMM. B, Significant immune-related pathways derived from GSEA of TERT methylation-related genes when comparing PMME and normal controls. The infiltration level differences of CD8⁺ T cells (C) and activated CD4⁺ memory T cells (D) in patients with TERThi and TERTlow PMME (*, P < 0.05). E, PFS differences between patients with TERThi and TERTlow NEMM receiving immunotherapy. F, Case demonstrations of 3 patients with PMME (P1, P7, and P13) who received anti-PD-1 immunotherapy during their treatment course. DDP, cisplatin.