Reduced Glutathione Peroxidase (GPx) Activity in Patients with Cutaneous Leishmaniasis

Background: Cutaneous leishmaniasis (CL) is a tropical parasitic infection that involves several factors in its pathogenesis, including oxidative stress. The oxidative stress in CL may deplete antioxidant nutrients. Objectives: The aim of the study was to measure glutathione peroxidase (GPx) activity in patients with CL. Methods: The investigation included 80 patients with CL and 80 healthy participants. A diagnostic kit was used to measure GPx activity. Results: The results showed a significant decrease in GPx activity in the CL patient group compared to the control group (P < 0.001), which is related to increased oxidative stress in patients. Conclusions: According to the results, GPx enzyme activity can serve as a biomarker for the diagnosis, prognosis, and monitoring of treatment in patients with CL.