The condition of newborns and the course of the early neonatal period in children from mothers who had complications from the group of great obstetric syndromes

Aim of research - to study the peculiarities of the course of the antenatal and early postnatal period in children from mothers who had complications from the group of great obstetric syndromes (GOS), in order to improve the algorithm of their management. Materials and methods. 239 newborns from pregnant women (the main group - MG) who had complications from the group of GOS, were examined. The control group (CG) consisted of newborns from 56 almost healthy pregnant women with a good reproductive history and an uncomplicated course of this pregnancy. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistical 6.0 programs. Results. Newborns in the CG were significantly smaller in all anthropometric indicators compared to newborns in the CG, fetal growth restriction syndrome was observed in 41 (17.2%) newborns in the CG, while absent in CG. The condition of newborns according to the Apgar scale in 180 (75.3%) children of MG ranged from 5 to 7 points, >7 - in 59 (24.7%) (average value - 6.8±0.91), in CG - 7 ,9±0.73, at 5 minutes in 212 (88.7%) newborns >7 points. In the MG, 81 (33.9%) children were born in a state of asphyxia, which led to hypoxic-ischemic injury of the central nervous system in 54 (22.5%) newborns from mothers in the MG. Increased nerve excitability, small-scale tremor, horizontal nystagmus and low muscle tone were observed in 26 (10.8%) children, and generalized weakness - in 14 (5.9%) children from MG and 2 (3.6%) children from CG. Conclusions. The conducted study showed that children born to mothers with clinical manifestations of GОS (premature birth, placental insufficiency, preeclampsia) have a high incidence of complications in the antenatal and early neonatal period, in particular, fetal growth restriction syndrome, distress in childbirth, asphyxia, hypoxic-ischemic injury to the central nervous system, conjugation jaundice, respiratory distress syndrome, as well as weight loss in newborns. The research carried out in accordance with principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of women was obtained for conducting the studies. No conflict of interests was declared by the authors.