May 27, 2024Scientific AfricanOpen Access

Involvement of catecholaminergic and nitric oxide–cGMP pathways in the antidepressant-like effects of hydroethanolic leaf extract of Morinda Longiflora G. Don in Mice

View Full Paper

Ask AI

Bookmark

Immobility times in the forced swim test and tail suspension test decreased significantly following oral administration of Morinda longiflora leaf extract in mice.
Doses of 30 to 300 mg/kg of the extract markedly reduced immobility in the open space swim test without altering spontaneous open field locomotor activity.
These antidepressant findings highlight modulation of the catecholaminergic pathway and nitric oxide-cgmp pathway; mouse model, further preclinical work needed.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Animal study demonstrates antidepressant-like effects of Morinda longiflora extract in mice, suggesting catecholaminergic and nitric oxide pathway involvement.

Cite This Study

Addae et al. (2024) studied this question.

synapsesocial.com/papers/68e68498b6db64358760d361 https://doi.org/10.1016/j.sciaf.2024.e02267

View Full Paper

Ask AI

Bookmark

Implication

Animal study demonstrates antidepressant-like effects of Morinda longiflora extract in mice, suggesting catecholaminergic and nitric oxide pathway involvement.

Involvement of catecholaminergic and nitric oxide–cGMP pathways in the antidepressant-like effects of hydroethanolic leaf extract of Morinda Longiflora G. Don in Mice

Key Points

Discussion

Implication

Cite This Study

Involvement of catecholaminergic and nitric oxide–cGMP pathways in the antidepressant-like effects of hydroethanolic leaf extract of Morinda Longiflora G. Don in Mice

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider