58 Comparing the outcomes of percutaneous coronary intervention seen in patients with varying stages of chronic kidney disease to those with normal renal function

Introduction Approximately 2.8 million UK patients have chronic kidney disease (CKD), a risk factor associated with coronary artery disease. Despite this, CKD patients are frequently excluded from percutaneous coronary intervention (PCI) trials, potentially due to perceived contrast-induced risks. However, PCI is still a treatment often used in managing cardiac ischaemia in CKD patients. Purpose To describe and compare the outcomes of patients undergoing PCI with varying degrees of CKD and to compare them to those with normal renal function. Methods Hospital data from June 2020–2023 was analysed, excluding those with unknown renal status or functioning transplants. 2505 were identified, of which 9 were excluded. The remaining 2495 were grouped into those with no renal impairment (2385), those with stage 3/4 CKD not on dialysis (50) and those on dialysis (60). Table 1 outlines the baseline characteristics. MACE was defined as myocardial infarction, cerebrovascular accident and renal failure. Other identified complications included re-infarction and blood transfusions. Complication rates between those with renal impairment and those without were compared. Statistical difference was measured using the chi-squared test. Results Analysis of baseline characteristics shows that those with renal impairment had a statistically significant increase in incidence of diabetes and hypertension (p<0.05). There was no significant difference in age or sex between the groups. Table 2 outlines the results. Those with CKD experienced a statistically significant higher incidence of MACE (7.27 vs. 1.30%, p<0.05). There was a significant difference in mortality rates between renal impairment and no renal impairment groups (9.10% vs 2.55%, p <0.05). The dialysis group had a significantly higher all-cause mortality than the non-renal impairment group (14.00.% vs 2.55%, p<0.05), whereas the increase seen in the non-dialysis group was insignificant. Conclusion Patients with CKD undergoing PCI have a high morbidity and mortality rate, with those on dialysis having worse outcomes than those with CKD stage 3/4 and not on dialysis. This analysis highlights the increased risk in patients with renal impairment and allows decision-making and complications to be discussed prior to PCI procedure. Conflict of Interest None