Anti-Inflammatory Effectiveness of Aloe Vera Extract Gel Based on the Number of Macrophages in Post Tooth Extraction Socket Wound of Wistar White Rats

Objective: This study aims to determine the effectiveness of anti-inflammatory gel aloe vera extract (Aloe vera) with the concentration of 25%, 50%, 75% on the number of macrophage cells in the socket wound after tooth extraction in white wistar rats. Methods: This research is a laboratory experimental research. The research design used was a simple post-test experimental design. Forty-six male wistar rats were divided into four groups, namely the group given 25%, 50% and 75% Aloe vera extract gel after extraction. On the rat tooth that had been extracted, 0.1 ml of Aloe vera gel was applied to cover the socket wound. Experimental animals were sacrificed after the first and third day of treatment. The sacrifice was made decapitation. After that, tissue sampling and staining were carried out and the number of macrophage cells counted in the smear was observed using a binocular microscope with 400x magnification to obtain a counting area. Data processing was carried out using the SPSS application. Results: Normality test with Shapiro Wilk test followed by one way ANOVA and Post hoc LSD tests (p<0.05). Data analysis showed some significant differences in the number of macrophages on the first and third day’s socket wounds in the 25%, 50% and 75% Aloe vera extract gel groups. Conclusion: The results of this research is the 75% Aloe vera extract gel group had more effective anti-inflammatory results against the number of macrophages than the control group and the other Aloe vera extract gel groups.