Survival Analysis of Thymus Epithelial Tumors, Experience of an Oncological Center in Mexico

Background: Thymus epithelial neoplasms are rare tumors, with a reported incidence of 0.13:100,000 person/year. The basis of treatment is surgical and postoperative radiotherapy has shown improvement in overall survival. In case of being unresectable, the therapy of choice would be systemic. Due to the frequency of the disease, there are few studies to help us regulate our behavior. Our objective is To identify and describe the characteristics and the oncological results of this tumors. Methods: Retrospective, descriptive and analytical cohort study, conducted in a single center. A descriptive and exploratory analysis was done to know the behavior of the data. For survival analysis, Kaplan - Meier curves and Log Rank analysis were used. Univariate and multivariate analyses were performed. Results: in a period of 10 years, a sample of 18 patients was obtained. 17% were carcinomas and the rest thymomas. The median survival was 36.9 months; for thymoma 62.3 and carcinoma 27.2 (p=0.04). In relation to the clinical stages of both Masaoka and TNM, had a mean survival of 90.8 months for localized or crazy advanced stages, and 33.8 for stage IV (p = 0.022). Conclusions: In Mexico there is lack of information regarding these neoplasms. We found 18 cases, the characteristics of the cases have similarities in relation to other works. In the survival analysis we found higher risk to higher clinical stage, both Masaoka and TNM and histology of the WHO. We present one of the first cohorts of thymus epithelial tumors in Mexico.