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May 26, 2024AgingOpen Access

Effects of PM2.5 on mucus hypersecretion in airway through miR-133b-5p/EGFR/Claudin1/MUC5AC axis

Lerong Chen Liangliang Wu Xiaopeng Cheng Jianhua Huang Jianping Peng

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Abstract

To investigate the role of the EGFR/MAPK signaling pathway in PM2.5 in promoting the MUC5AC hypersecretion in airway and exacerbating airway inflammation.

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Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e6859fb6db64358760e7c1 https://doi.org/10.18632/aging.205785

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Activation of Notch1-GATA3 pathway in asthma bronchial epithelial cells induced by acute PM2.5 exposure and the potential protective role of microRNA-139-5p2024 · 5 citations
2Airborne fine particulate matter causes murine bronchial hyperreactivity via MAPK pathway‐mediated M 3 muscarinic receptor upregulationOriginal Research · 2016 · 11 citations
3PM2.5 Induced the Expression of Fibrogenic Mediators via HMGB1-RAGE Signaling in Human Airway Epithelial CellsOriginal Research · 2018 · 25 citations
4Exosomal miR-2110 from PM2.5-Exposed Lung Epithelial Cells Targets SRSF1 to Promote M1 Macrophage Polarization and Inflammatory Responses in COPDIn Vitro Study · 2026
5MiR-155-5p Differentially Regulates IL-13Rα1 and IL-13Rα2 Expression and Signalling, Driving Abnormal Lung Epithelial Cell Phenotype in Severe Asthma2024 · 2 citations

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Research Progress on the Mechanisms of High Mucus Secretion in the Airway: A Scoping Review2026
D21-16 Muc1, Muc4 and Ceacam5 Expression Are Elevated in Severe Asthma and Correlate With the Degree of Obstruction and Prospective Exacerbations2026
PM2.5 Exacerbates Airway Inflammation and Epithelial Barrier Disruption in Chronic Obstructive Pulmonary Disease Mice Through the RAGE‐Dependent PERK/eIF2α/ATF4/CHOP Pathway2026

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