Cancer is one of the leading causes of death worldwide, characterized by ineffective treatments approaches and increasing resistance to conventional chemotherapeutics.Considering these challenges, this study aims to assess the potential of essential oils as a therapeutic alternative.The research specifically focuses on investigating the cytotoxic effect in tumor cells within in vitro and in vivo models when essential oils are employed as a therapy in comparison to traditional drugs for managing oral cancer.Comprehensive search was conducted across various scientific databases, resulting in the inclusion of 16 studies within this systematic review.The gathered data strongly suggest that essential oils exhibit significant efficacy in inhibiting cell viability, particularly when utilized as a substitute therapy for oral cancer.
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