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May 24, 2024Journal of Integrative MedicineOpen Access

Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

Lihua Zhu Yupei Liang Lian Yang Feng Zhu Lijun Jia Hegen Li

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Abstract

Studies have demonstrated that cycloastragenol induces antitumor effects in prostate, colorectal and gastric cancers; however, its efficacy for inhibiting the proliferation of lung cancer cells is largely unexplored. This study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer (NSCLC) and elucidates the underlying molecular mechanisms.

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Cite This Study

Zhu et al. (2024) studied this question.

synapsesocial.com/papers/68e68856b6db643587610323 https://doi.org/10.1016/j.joim.2024.05.004

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cycloastragenol Inhibits Colorectal Cancer Cell Metastasis via Epithelial–Mesenchymal Transition and the <scp>PI3K</scp> Signalling PathwayOriginal Research · 2026
2Cycloastragenol Exerts Antiapoptotic Effect on Human Lymphocytes under UV-Irradiation2025
3Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer2024 · 28 citations
4Exploring the Therapeutic Targets and Molecular Mechanisms of Astragalus in Lung Cancer by Integrated Computational Analysis2024
5Estragole Induces Apoptosis in A549 Lung Cancer Cells via ROS-mediated Oxidative Stress and Modulation of Caspase Activation and Bax/Bcl-2 PathwayOriginal Research · 2026

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