Experimental results show that cycloastragenol reduces apoptosis in lymphocytes exposed to UV-irradiation and hydrogen peroxide, suggesting protective benefits.
Changes in the level of some markers of apoptosis (lipid asymmetry of plasma membranes, production of reactive oxygen species, nitric oxide, concentration of ionized calcium) of human blood lymphocytes modified by exposure to hydrogen peroxide (10 mol/l) and UV light (254 nm, 1510 J/m) in the presence of cycloastragenol (10–10 mol/l) were studied. The intensity of apoptotic lymphocyte death processes was found to decrease after UV-light exposure in the presence of cycloastragenol (10 mol/l). The cytoprotective effect of cycloastragenol on lymphocytes was found to be due to a decrease in the level of intracellular reactive oxygen species and calcium ions, an increase in the activity of catalase and glutathione reductase and nitric oxide production. Possible mechanisms of cycloastragenol action as a regulator of apoptotic death of lymphocytes induced by UV radiation and hydrogen peroxide exposure are discussed.
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Nakvasina Ma (2025) studied this question.
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