Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source

The trifluoromethoxy moiety, an emerging fluorinated group, shows interesting properties for pharmaceutical and agrochemical applications. However, only few methods have been reported for the direct introduction of this group on molecules with high efficiency, safety and low cost. Indeed, most of direct trifluoromethoxylation reagents are either expensive, hazardous or require preliminary synthesis before their use. Here we describe the use of 2,4‐dinitro‐1‐(trifluoromethoxy)benzene (DNTFB) as an easy‐to‐handle, safe, commercially available and cheap source of trifluoromethoxide anion for the trifluoromethoxylation of arynes.