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May 24, 2024Journal of Pharmaceutical AnalysisOpen Access

Cirsium japonicum mitigates allergic nasal inflammation by regulating NRF2-mediated mucin production: systematic transcriptome and molecular docking analyses

Bo‐Jeong Pyun Su‐Jin Baek Kyuhyung Jo Ik Soo Lee Musun Park Hye Jin Kim Joo Young Lee Susanna Choi Yun Hee Kim Taesoo Kim

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Abstract

• Cirsium japonicum (CSJ) alleviates ovalbumin (OVA)-induced allergic rhinitis (AR) • CSJ reduces serum anti-OVA IgE, histamine, and IL-13 levels and nasal inflammation • O-Linked glycosylation of mucins, MUC5AC, and NRF2 are key targets of CSJ in AR • Cryptochlorogenic acid and cirsimarin in CSJ bind directly to NRF2–KEAP1 and MUC5AC • CSJ shows potential for AR therapeutic agent via the NRF2 pathway and MUC5AC expression regulation

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Cite This Study

Pyun et al. (2024) studied this question.

synapsesocial.com/papers/68e6897cb6db643587611400 https://doi.org/10.1016/j.jpha.2024.101000

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