What question did this study set out to answer?

This research aims to evaluate the effectiveness of alpha-linolenic acid in alleviating allergic rhinitis and to understand the underlying mechanisms.

June 6, 2026Scientific ReportsOpen Access

α-Linolenic acid alleviates ovalbumin-induced allergic rhinitis in mice and modulates GPR120–NF-κB signaling

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Authors

YSYulan SongNingbo University FZFengyao ZhangShanxi Medical University YZYan ZhaoShanxi Medical University

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Implication

Randomized trial demonstrates reduced allergic rhinitis symptoms in mice following alpha-linolenic acid intervention, suggesting its therapeutic potential.

Key Points

This research aims to evaluate the effectiveness of alpha-linolenic acid in alleviating allergic rhinitis and to understand the underlying mechanisms.
Utilized an ovalbumin-sensitized mouse model to assess allergic rhinitis symptoms.
Employed histological techniques and serum assays to evaluate nasal mucosal pathology and inflammatory markers.
Analyzed signaling pathways in nasal mucosa using immunohistochemistry, qRT-PCR, and Western blotting.
ALA significantly reduced nasal symptoms and improved nasal mucosal damage in the AR mouse model.
Decreased serum levels of OVA-specific IgE, IL-4, IL-6, and IL-1β were observed, while IFN-γ levels were increased.
Inhibition of NF-κB signaling pathway was noted, indicated by reduced phosphorylation of IKK and NF-κB p65.

Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a23b94671a5da9775e753e9 https://doi.org/10.1038/s41598-026-53416-4

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Implication

Randomized trial demonstrates reduced allergic rhinitis symptoms in mice following alpha-linolenic acid intervention, suggesting its therapeutic potential.

α-Linolenic acid alleviates ovalbumin-induced allergic rhinitis in mice and modulates GPR120–NF-κB signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

α-Linolenic acid alleviates ovalbumin-induced allergic rhinitis in mice and modulates GPR120–NF-κB signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

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