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Abstract Asthma presents as a chronic allergic condition characterized by airway inflammation, increased responsiveness, and mucus accumulation. Reactive oxygen species (ROS) are central to its inflammatory cascade and pathology. Hence, we theorized that antioxidants could offer a promising therapeutic strategy for house dust mite (HDM)-induced asthma. Our study reveals that Tea Polyphenols (TPs) encapsulated in biocompatible nanoparticles, enveloped with platelet membranes (PM@TP/NPs), effectively alleviated HDM-induced asthma by suppressing ROS production and modulating the CCL2/MAPK signaling pathway. Notably, PM@TP/NPs exhibited excellent biocompatibility and safety, with enhanced lung retention compared to free TP. In vitro experiments demonstrated that PM@TP/NPs curbed HDM-induced inflammation in human bronchial epithelial (HBE) cells by reducing ROS levels, Ccl2 mRNA expression, and inhibiting the MAPK pathway. In an HDM-induced mouse asthma model, inhalation of PM@TP/NPs significantly attenuated lung inflammation, characterized by reduced eosinophil infiltration and secretion of type 2 pro-inflammatory factors. Furthermore, PM@TP/NPs enhanced ROS scavenging capacity while concurrently suppressing the CCL2/MAPK pathway in the lungs of asthmatic mice. Collectively, our findings propose PM@TP/NPs as a novel therapeutic strategy for asthma, targeting ROS production and inflammation for potential clinical application.
Ouyang et al. (Fri,) studied this question.