Animal study demonstrates that MnTE-2-PyP reduces lung oxidative stress markers in asthmatic mice, suggesting a protective antioxidant role in airway inflammation.
AIM: To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. MATERIAL AND METHODS: The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. RESULTS: The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. CONCLUSIONS: The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.
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Terziev et al. (2012) studied this question.
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