FIGURE 2 from Use of Deep Learning to Evaluate Tumor Microenvironmental Features for Prediction of Colon Cancer Recurrence

Artificial intelligence–derived morphologic features in stage III colon cancers (NCCTG N0147 trial) that were found to be most strongly associated with patient TTR. Data are shown in Kaplan–Meier plots for TSR among p-MMR tumors in initial cohort (A), validation cohort (B), and % inflammatory stroma among d-MMR tumors in initial cohort (C) and validation cohort (D). TSR is shown by level (level 1 < 0.65; level 2 ≥ 0.65). Inflammatory stroma level includes level 1 (<7.38), level 2 (≥7.38 and <15.22), level 3 (≥15.22 and <36.75), level 4 (≥36.75).