Influence of Peripheral Stress-Limiting System Disorders on the Course of Pregnancy in Women With Preeclampsia

The aim of research. To study the eff ect of peripheral stress- limiting system disorders on the course of pregnancy in women with preeclampsia (PE).Material and methods. A clinical and statistical analysis of the course of pregnancy in 34 patients with PE (main group) was performed. Of these, 20 had moderate PE (group I) and 14 had severe PE (group II). The control group consisted of 20 healthy women. Indicators of lipid peroxidation (LPO) and antioxidant system (AOS) protection were studied at 24-26 and 34-36 weeks of pregnancy.Research results. In pregnant women with PE, disturbances in the lipid peroxidation system of the AOS were revealed. Against the background of excessive activation of lipid peroxidation in women of group I, there is an AOS defi ciency, as evidenced by the absence of an increase in glutathione and glutathione peroxidase at 34-36 weeks (p>0.05). In group II, glutathione peroxidase did not increase (p>0.05). Glutathione activity did not increase at 24-26 weeks (p>0.05), and at 34-36 weeks it signifi cantly decreased, indicating the depletion of the AOS defense. This had a negative impact on the functional state of the body of pregnant women, contributed to the progression of the severity of PE and a signifi cant increase in the incidence of complications during pregnancy.Conclusions. An increase in the level of ROS products in the mother’s blood precedes the clinical manifestation of oxidative stress and correlates with the severity of PE. Pregnant women with moderate PE have antioxidant defi ciency and stress of compensatory and adaptive mechanisms of the mother’s body. In pregnant women with severe PE, there is a depletion of the body’s antioxidant defense and a possible failure of compensatory and adaptive mechanisms. The frequency of complications of pregnancy in women with severe PE is signifi cantly higher than in women with moderate PE. Levels of reduced glutathione and glutathione peroxidase activity can be considered as biochemical markers of impaired compensatory and adaptive mechanisms of maternal defense.