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May 21, 2024Proceedings of the National Academy of SciencesOpen Access

Construction of human 3D striato-nigral assembloids to recapitulate medium spiny neuronal projection defects in Huntington’s disease

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Authors

SWShanshan WuYHYuan HongCCChu Chu

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Wu et al. (2024) studied this question.

synapsesocial.com/papers/68e690f6b6db643587617bb9https://doi.org/10.1073/pnas.2316176121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model2025
  2. 2Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease2024 · 5 citations
  3. 3Huntington’s Disease Human Lateral Ganglionic Eminence Precursors Differentiate into Functionally Mature Medium Spiny Neurons Exhibiting Pathology2026
  4. 4Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington’s disease2024 · 1 citations
  5. 5Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 mice2024