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May 1, 2024Open Access

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 mice

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Authors

DSDanielle A. SimmonsStanford UniversitySSSridhar SelvarajCalifornia Institute for Regenerative MedicineTCTingshuo ChenStanford University

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Cite This Study

Simmons et al. (2024) studied this question.

synapsesocial.com/papers/68e6c4bab6db643587643d08https://doi.org/10.1101/2024.05.01.592095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain1997 · 2,935 citations
  2. 2The role of the striatum in social behavior2013 · 323 citations
  3. 3Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington’s Disease2023 · 12 citations
  4. 4A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease2013 · 149 citations
  5. 5Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington’s disease mice and innervate the striatum2023 · 17 citations