Comparative evaluation reveals lower hypomagnesaemia rates with voclosporin versus tacrolimus in clinical use, suggesting divergent distal tubule mechanisms.
Calcineurin inhibitors (CNIs) affect kidney electrolyte handling and blood pressure (BP) through an effect on the distal tubule. The second-generation CNI voclosporin causes hypomagnesaemia and hypercalciuria less often than tacrolimus. This suggests different effects on the distal tubule, but this has not yet been investigated experimentally.
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Wei et al. (2024) studied this question.
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