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May 21, 2024Open Access

Exploring the Antidiabetic Potential of Neocarya macrophylla (Nm) Leaf Fractions: A Comprehensive Study on Hypoglycemic Activity, Body Mass Index, and Hematological Parameters in High-Fat Diet/ Streptozotocin-Induced Diabetic Rat

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Authors

SMSadiq MaifataAYAmina Jega YusufZUZayyanu Umar Usman

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Overview

Animal study demonstrates reduced blood glucose and improved blood count indices from Neocarya macrophylla in diabetic rats, highlighting its potential antidiabetic value.

Key Points

  • Ethyl acetate fraction of Neocarya macrophylla leaves lowered blood glucose levels significantly in diabetic rats, and it concurrently attenuated body mass index.
  • In a streptozotocin-induced diabetic rat model, 120 mg/kg of ethyl acetate fraction lowered blood glucose by 28.9% at 4 hours and restored normal platelet counts.
  • Highlights therapeutic potential for managing diabetes mellitus and hematological complications—rat model; further mechanistic and clinical research is needed.

Cite This Study

Maifata et al. (2024) studied this question.

synapsesocial.com/papers/68e69229b6db643587618cf4https://doi.org/10.20944/preprints202405.1362.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoglyceamic and Hepatoprotective Potentials of Dichloromethane (DCM) Fraction of Gongronema Latifolium Extract in Streptozotocin-Induced Diabetic Wistar Rats2024
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  3. 3Effects of combined methanol extracts of Nauclea latifolia and Voacanga africana leaves on some biochemical indices of alloxan-induced diabetes in albino rats2024
  4. 4Therapeutic potential of bark extracts from <i>Macaranga denticulata</i> on renal fibrosis in streptozotocin-induced diabetic rats2024 · 3 citations
  5. 5Centratherum Anthelminticum (L.) Kuntze Seed Oil Restoring Hepatic Balance in Type 2 Diabetic Rats through Nrf2/Keap1/HO-1 and NF-κB Pathway Modulation2025