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May 21, 2024Life Science AllianceOpen Access

NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53

Shunsuke Hanaki Makoto Habara Haruki Tomiyasu Yuki Sato Yosei Miki Takahiro Masaki Shusaku Shibutani Midori Shimada

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Abstract

FK506-binding protein 52 (FKBP52) is a member of the FKBP family of proline isomerases. FKBP52 is up-regulated in various cancers and functions as a positive regulator of steroid hormone receptors. Depletion of FKBP52 is known to inhibit cell proliferation; however, the detailed mechanism remains poorly understood. In this study, we found that FKBP52 depletion decreased

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Hanaki et al. (2024) studied this question.

synapsesocial.com/papers/68e69229b6db643587618e1e https://doi.org/10.26508/lsa.202302426

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1FKBP52 in cancer biology and therapy: molecular mechanisms, signalling networks, and drug targeting of the FKBP protein familyReview · 2026
2Abstract 1482: FKBP52 drives diverse HCC phenotypes through context-dependent targeting of p532024
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