May 20, 2024CureusOpen Access

Association of Apolipoprotein E (APOE) Polymorphisms With Serological Lipid and Inflammatory Markers

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Authors

HKHari Krishnan KrishnamurthyVibrant Data (United States)IRImbaasree RajaveluVibrant Data (United States)SRSwarnkumar ReddyVibrant Data (United States)

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Implication

Laboratory analysis reveals dysregulated lipid and inflammatory profiles in APOE ε4 carriers, highlighting increased cardiovascular and Alzheimer disease risks.

Key Points

Apolipoprotein E ε4 alleles promote atherogenic lipid and inflammatory alterations, characterized by dysregulated cholesterol metabolism compared to the E3/E3 genotype.
Among 915 individuals tested via PCR-RFLP, carriers of ε4 alleles exhibited elevated total cholesterol, myeloperoxidase, and high-density lipoprotein changes.
Highlights that early APOE genotyping may guide targeted dietary and therapeutic interventions, mitigating disease risks driven by abnormal triglycerides and lipids.

Cite This Study

Krishnamurthy et al. (2024) studied this question.

synapsesocial.com/papers/68e69377b6db64358761aa00 https://doi.org/10.7759/cureus.60721

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Implication

Laboratory analysis reveals dysregulated lipid and inflammatory profiles in APOE ε4 carriers, highlighting increased cardiovascular and Alzheimer disease risks.

Association of Apolipoprotein E (APOE) Polymorphisms With Serological Lipid and Inflammatory Markers

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of Apolipoprotein E (APOE) Polymorphisms With Serological Lipid and Inflammatory Markers

Discussion

Member takes

Implication

Key Points

Cite This Study

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