Integrated Clinical Genotype-phenotype Characteristics of STAT3-mutated Myeloid Neoplasms

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Integrated analysis reveals clinical and genetic features of STAT3 mutations in myeloid neoplasms, highlighting rare gain-of-function alterations.

STAT3 activation in myeloid neoplasms occurs primarily via phosphorylation, whereas direct gain-of-function mutations appear exceptionally rare in disease cohorts.
Clinical genotype-phenotype assessment reveals that aberrant transcription factor activity promotes cancer progression through distinct phosphorylation mechanisms.
Highlights the need to characterize rare STAT3 mutations alongside phosphorylation events to clarify oncogenic pathways and refine classification in myeloid neoplasms.

Ye et al. (2024) studied this question.

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Integrated analysis reveals clinical and genetic features of STAT3 mutations in myeloid neoplasms, highlighting rare gain-of-function alterations.