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May 18, 2024Journal of Applied GlycoscienceOpen Access

Thermotolerance Mechanism of Fungal GH6 Cellobiohydrolase. Part I. Characterization of Thermotolerant Mutant from the Basidiomycete Phanerochaete chrysosporium

Sora Yamaguchi Naoki Sunagawa Masahiro Samejima Kiyohiko Igarashi

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Abstract

Cellobiohydrolase (CBH), belonging to glycoside hydrolase family 6 (GH6), plays an essential role in cellulose saccharification, but its low thermotolerance presents a challenge in improving the reaction efficiency. Based on a report that chimeric CBH II (GH6) engineered to remove non-disulfide-bonded free Cys shows increased thermotolerance, we previously mutated the two free Cys residues to Ser in GH6 CBH from the basidiomycete

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Cite This Study

Yamaguchi et al. (2024) studied this question.

synapsesocial.com/papers/68e69710b6db64358761dcad https://doi.org/10.5458/jag.jag.jag-2023_0017

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