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May 18, 2024Journal of Coordination Chemistry

Synthesis, crystal structures and urease inhibition of nickel(II), copper(II), zinc(II) and molybdenum(VI) complexes derived from N,n’ -bis(4-bromosalicylidene)-1,3-propanediamine

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Authors

HCHai-Ying ChenRLRundong LuJLJinkai Lei

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Overview

In vitro experiment reveals effective urease inhibition by nickel and copper Schiff base complexes, highlighting potential therapeutic applications.

Key Points

  • Novel trinuclear complexes of nickel and copper derived from a bis-schiff base show effective urease inhibition, whereas zinc and molybdenum analogues exhibit different profiles.
  • Structural determination reveals bridged phenolate oxygen donors across metal centers, giving nickel an octahedral coordination environment and copper square pyramidal geometry.
  • Single crystal x-ray diffraction alongside spectroscopy confirmed the geometries of four distinct complexes, providing structural foundations for targeted urease inhibition.

Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e69843b6db64358761e478https://doi.org/10.1080/00958972.2024.2357722
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis, Crystal Structures and Urease Inhibition of Copper(II) and Zinc(II) Complexes Derived from N,N’-Bis(4-bromosalicylidene)-1,3-propanediamine2024
  2. 2Synthesis, crystal structures and urease inhibition of copper(II), manganese(III) and nickel(II) complexes derived from 2-bromo- N′ -(2-hydroxy-4-methoxybenzylidene) benzohydrazide2026
  3. 3Synthesis, crystal structures and urease inhibition of isostructural tetranuclear nickel(II)-zinc(II) complexes derived from 2-(((2-hydroxyphenyl)imino) methyl)-6-methoxyphenol2026
  4. 4theses, Crystal Structures and Antimicrobial Activity of Copper(II) Complexes with the Ligand N,N’-Bis(4-bromosalicylidene)propane-1,2-diamine2024 · 1 citations
  5. 5Coordination of N, O-donor Appended Schiff Base Ligand N, N’-bis (3-Methoxy Salicylidenimino-1,3-diaminopropane) towards Nickel (II), Copper (II) and Zinc (II) : Synthèses, Crystal Structure2024