Endoscopic hand suturing with clips for a large defect after endoscopic full-thickness resection of gastric gastrointestinal stromal tumor

Few studies have focused on endoscopic full-thickness resection (EFTR) for gastric gastrointestinal stromal tumors (g-GISTs) ≥35 mm [1], which could be attributed to the difficulty of endoscopic resection and closure of the defect, although multiple closure techniques have been developed for post-EFTR defects [2] [3] [4]. Recently, endoscopic hand-suturing (EHS) has been proved safe and effective for gastrointestinal superficial defects [5], and can be expected to be similarly efficacious for closing large defects after EFTR. Here, we describe a successful case of full-thickness closure using EHS with clips (EHS-Clips) for a large g-GIST defect.