Evaluation of In Vitro Cytocompatibility of New Dental Restorative Composite Resin Copolymers Containing 2π + 2π Photodimerized Cinnamyl Methacrylate Crosslinker

Leached monomeric residuum and their noxious metabolites [methyl ester of 2,3-epoxy-2-methyl-propanoic acid, methacrylic IntroductIonDental restorative materials will be in direct or indirect contact with the hard and soft tissues of the oral cavity.These restorative materials undergo compositional aberrations at the surface or core level due to constant thermo-chemicomechanical stimuli.These stimuli cause the release of residual chemicals and their metabolites that might induce alterations in the mucosal and submucosal tissues.Among the tissue alterations, hypersensitivity changes, including oral lichenoid or anaphylactoid reactions, are common due to mucosal abuse. 1 Tissue fibrosis with the restorative materials was also reported, and it ensued due to chronic tissue contact. 2 Among the restorative materials, >12% of untoward cytotoxic reactions are engendered by restorative composite resins (RCR) alone. 3The amount and chemical type of a leached organic constituent is accountable for dictating the RCR's biocompatibility. 4Leached detrimental residual components from the RCR are known dentinal penetrants and diffusers that harm the pulpal tissues by deteriorating the tooth's vitality. 5he base matrix forming monomers (B) in the RCR including bisphenol-A-glycerolate dimethacrylate (Bis-GMA) and diurethane dimethacrylate (DUDMA) along with diluent monomers (D) triethylene glycol dimethacrylate (TEGDMA) and 2-hydroxy-ethyl methacrylate have been studied significantly in their homo-/ copolymeric forms concerning physicomechanical properties.