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May 16, 2024Microbiology SpectrumOpen Access

Enterovirus A71 crosses a human blood–brain barrier model through infected immune cells

Léa Gaume Hélène Chabrolles Maxime Bisseux Igor Lopez-Coqueiro Lucie Dehouck Audrey Mirand Cécile Henquell Fabien Gosselet Christine Archimbaud Jean‐Luc Bailly

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Abstract

Enterovirus A71 (EV-A71) is associated with neurological conditions such as acute meningitis and encephalitis. The virus is detected in the bloodstream, and high blood viral loads are associated with central nervous system (CNS) manifestations. We used an

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Gaume et al. (2024) studied this question.

synapsesocial.com/papers/68e69b09b6db643587620fa4 https://doi.org/10.1128/spectrum.00690-24

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Enterovirus‐71 utilizes small extracellular vesicles to cross the blood–brain barrier for infecting the central nervous system via transcytosispreclinical · 2022 · 30 citations
2Enterovirus A71 exploits peripheral circulating extracellular vesicles to facilitate blood-brain barrier permeabilityOriginal Research · 2026
3A Mouse Model for Infection with Enterovirus A71 in Small Extracellular Vesiclespreclinical · 2020 · 18 citations
4Genotype-dependent cell tropism of EV-A71 at the human blood cerebrospinal fluid and blood brain barrierpreclinical · 2025 · 2 citations
5The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragmentspreclinical · 2010 · 27 citations

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Enterovirus 71 Infection of Monocytes with Antibody-Dependent Enhancement2010
Enterovirus 71: epidemiology, pathogenesis and management2009
Enterovirus-A71 Preferentially Infects and Replicates in Human Motor Neurons, Inducing Neurodegeneration by Ferroptosis2024

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