Population
Human peripheral blood monocytes and monocytic cell line THP-1
Design
Preclinical
Authors
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Supports ADE of EV71 in monocytes; hypothesis-generating for pathogenesis and vaccine safety in humans.
Antibody-dependent enhancement augments EV71 infectivity in human monocytes, which may contribute to age-dependent pathogenesis and has implications for vaccine development.
Wang et al. (2010) studied this question.
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