March 8, 2011Virology JournalOpen Access

Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo

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Population

Human monocytic cells (THP-1) and 1-day-old Kunming mice

Comparison

EV71 pre-incubated with sub-neutralizing… vs EV71 pre-incubated with PBS, or primary…

Design

Preclinical

Follow-up

14-15 days

Authors

JHJianfeng HanLanzhou University of Technology RCRuiyuan CaoXinjiang Medical University YDYong‐Qiang DengShenzhen University

Discussion

Member takes

Implication

Does not yet alter IVIG use in EV71; hypothesis-generating for ADE role in severe human disease.

Structured PICO

Population

Human monocytic cells (THP-1) and 1-day-old Kunming mice

Intervention

EV71 pre-incubated with sub-neutralizing concentrations of human Intravenous Immunoglobulin (IVIG), or primary infection with avirulent EV71 strain HN08/08

Comparator

EV71 pre-incubated with PBS, or primary injection with PBS

Outcome

Viral yield in vitro and mortality in vivo (over 14-15 days)hard clinical

Sub-neutralizing antibodies can enhance EV71 infection in vitro and in vivo, suggesting antibody-dependent enhancement may contribute to the pathogenesis of severe EV71 infection.

Limitations

Mechanism for ADE of EV71 infection is still unknown
Target cells of EV71 in human tissues and organs have not been identified

Cite This Study

Han et al. (2011) studied this question.

synapsesocial.com/papers/6a7ccf3021c5894b35c8a169 https://doi.org/10.1186/1743-422x-8-106

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Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider