Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections.The risk factor for stunting is predominantly diseases during the 1000 days of life.The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results.This study aimed to identify stunting biomarkers based on the priority scoring of gene variants.Identification of stunting risk genes used the PubMed based-approach and HaploReg v4.1.We found 33 genes that were identified as stunting risk gene.We then prioritized based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL).Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17.This research demonstrates how genomic variants and bioinformatics approaches can reveal biological insights for stunting.