Natural Substances in the Adjuvant Therapy of Depression

This is the authors' abstract. We don't add key points for this paper.

Depression has serious impacts on health and is a common condition seen in clinical practice. The initial therapy for depression may include both psychotherapy and medication, with selective serotonin reuptake inhibitors considered first-line treatment. For those with a partial or incomplete response to treatment, additional medications may also be utilized. In some individuals with treatment-resistant depression, there may be a need for adjuvant therapies in addition to such medications. This article reviews the adjuvant use of natural substances in people with depression. Evidence for the use of curcumin, methylfolate, omega-3 fatty acids, zinc, probiotics, and vitamin D in this context is discussed.