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May 15, 2024Journal of Medicinal Chemistry

Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy

Shuanghu Wang Zhihua Kong Yaru Shi Chuxiao Shao Wei Wang Zhenhong Su Jin Liu Yingxing Zhou Xiaoting Fei Binbin Cheng Jianjun Chen Yiyu Lu Jian Xiao

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Abstract

In this work, a series of bifunctional PD-L1/CD73 (cluster of differentiation 73) small-molecule inhibitors were designed and synthesized. Among them,

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Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e69d64b6db643587623253 https://doi.org/10.1021/acs.jmedchem.4c00553

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