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May 15, 2024Pharmacological Research - Modern Chinese MedicineOpen Access

Amelioration of gastric ulcer using a hydro-alcoholic extract of Mangifera indica in Sprague Dawley rats by prevention of muco-oxidative stress

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Authors

NKNazma KhanMKMohammad KhushtarMRMd. Azizur Rahman

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Overview

Preclinical study demonstrates gastric ulcer protection by Mangifera indica extract in Sprague Dawley rats, suggesting therapeutic utility against drug-induced muco-oxidative injury.

Key Points

  • Mangifera indica kernel extract significantly ameliorates indomethacin-induced gastric ulcers in rats, reinforcing mucosal defense and suppressing tissue muco-oxidative stress.
  • Oral extract treatment of 1000 mg/kg/day raised superoxide dismutase and catalase, matching the gastroprotective efficacy achieved by 50 mg/kg/day of standard ranitidine therapy.
  • Assessment across six rat cohorts shows prevention of muco-oxidative stress and gastric ulcer formation, supporting botanical therapy while requiring validation beyond this rat model.

Cite This Study

Khan et al. (2024) studied this question.

synapsesocial.com/papers/68e69fffb6db643587623b96https://doi.org/10.1016/j.prmcm.2024.100442
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