Development and optimization of Lamotrigene containing Liposomal Transdermal Patches

Antiepileptic drugs are generally available as tablets for oral administration, but this can pose problems for patients who are unable to consume medications orally. Transdermal drug delivery is useful in such cases. There is therefore an unmet need for enhancement techniques with the potential of delivering high dose medications across the skin. The transdermal route of drug administration ensures systemic delivery of drug by applying a drug formulation onto intact as patch on healthy skin thus ensuring sustained drug release and bypass of first-pass metabolism. Transdermal drugs significantly deliver molecules in a potent quantity that overcome the conventional problems of oral dosing. Thus, the objective of the proposed study is to develop lamotrigene-loaded transdermal patch an effective substitute for the existing maintenance therapies used for controlling epileptic seizures. We embarked on the transdermal delivery of lamotrigene upon this scientific basis.