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October 8, 2025Lupus Science & MedicineOpen Access

Predictors of patient-reported outcomes phenotypes in SLE during remission: a cluster analysis approach

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Authors

EEElena ElefanteUniversity of PisaFCFrancy Cruz‐SanabriaFondazione Stella MarisLGLuca GualtieriUniversity of Pisa

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Implication

Cross-sectional analysis reveals distinct symptom profiles in systemic lupus erythematosus patients, suggesting tailored management.

Key Points

  • Two distinct clusters related to symptom burden emerged among SLE patients, indicating important health-related quality of life differences.
  • The ‘high symptom burden’ cluster was notably affected by factors like fibromyalgia and glucocorticoid treatment, impacting their quality of life.
  • Logistic regression highlighted that both fibromyalgia and glucocorticoid treatment were strong predictors of cluster membership among patients.
  • Assessing disease impact and patient-reported outcomes is vital, as it informs personalized treatment plans for SLE management.

Cite This Study

Elefante et al. (2025) studied this question.

synapsesocial.com/papers/68e6a0f4718ef0a556b33e17https://doi.org/10.1136/lupus-2025-001673
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcome clusters and their stability over 1 year in patients with SLE: self-reported and performance-based cognitive function, disease activity, mood and health-related quality of life2024 · 2 citations
  2. 2Systemic Lupus Erythematosus Symptom Clusters and Their Association With Patient‐Reported Outcomes and Treatment: Analysis of Real‐World Data2020 · 19 citations
  3. 3454 Discordance of patient and physician health status concerns in systemic lupus erythematosus2017 · 6 citations
  4. 4Disease activity, cumulative damage and quality of life in systematic lupus erythematosus: results of a cross-sectional study1997 · 78 citations