FIGURE 7 from Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

Circulating cytokine profile in plasma of control and tumor-bearing NSG mice. A, Increased circulating CXCL1 in mice bearing tumors from TKTB34-RAS and TKTB6-RAS cell lines compared with control mice. B–J, Elevated circulating cytokine levels of CCL11, GCSF, GMCSF, MCSF, TNFα, and IL12(70) in mice bearing tumors from TKTB34-RAS cell line. Differences in circulating IL6, IL13, and CCL5 did not reach statistical significance. K and L, Circulating CXCL5 and TGFβ were not affected in tumor-bearing mice.