This protocol aims to examine the association of calf-intestinal alkaline phosphatase (CIAP)-resistant alpha-synuclein phosphorylated at serine 129 (PSER129) and proteinase K (PK)-resistant alpha-synuclein (aSyn) in the mouse brain, particularly in M83 transgenic mice treated with preformed fibrils. M83 lines exhibit a notably higher abundance of endogenous PSER129 compared to wild-type mice.
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Choi et al. (2024) studied this question.
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